Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface
نویسندگان
چکیده
Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens. Interactions of these cells with Candida albicans have been shown to be critical not just in host responses, but also in fungal cell responses, regulating fungal morphology and gene expression profile. In this review, we will explore the interactions between C. albicans and epithelial cells, and discuss how these interactions affect our relationship with this fungus.
منابع مشابه
From Attachment to Damage: Defined Genes of Candida albicans Mediate Adhesion, Invasion and Damage during Interaction with Oral Epithelial Cells
Candida albicans frequently causes superficial infections by invading and damaging epithelial cells, but may also cause systemic infections by penetrating through epithelial barriers. C. albicans is an unusual pathogen because it can invade epithelial cells via two distinct mechanisms: induced endocytosis, analogous to facultative intracellular enteropathogenic bacteria, and active penetration,...
متن کامل1 Candida albicans specific genes : 2 distinct roles in host - pathogen interactions 3
19 Human fungal pathogens are distributed throughout their kingdom, suggesting that 20 pathogenic potential evolved independently. Candida albicans is the most virulent member 21 of the CUG clade of yeasts and a common cause of both superficial and invasive infections. 22 We therefore hypothesised that C. albicans possesses distinct pathogenicity mechanisms. In 23 silico genome subtraction and ...
متن کاملPathogenic interactions between Helicobacter pylori adhesion protein HopQ and human cell surface adhesion molecules CEACAMs in gastric epithelial cells
Objective(s): The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of Helicobacter pylori.Materials and Methods: The literature was searched on “PubMed” using different key words including Helicobacter pylori, CEACAM and gastric.<br ...
متن کاملCandida albicans and virulence factors that increases its pathogenicity
Candida albicans are yeasts frequently human commensal and it is the main cause of different forms of oral, superficial or systemic candidiasis. The transformation from a harmless commensal to a virulent pathogen under the conditions of a dysfunctional host defense system is attributable to an extensive repertoire of selectively expressed virulence determinants. Several virulence factors contri...
متن کاملEngineered Keratinized Oral Mucosa Decreased C. albicans Transition Through the Production of Keratins 10, 14, 16, and 19 by Oral Epithelial Cells
The aim of this study was to evaluate the link between Candida albicans growth and dimorphism and the production of keratins by oral epithelial cells. Various culture models (monolayer and non-keratinized and keratinized engineered human oral mucosa) were produced and used for this purpose. Cell morphology, tissue structure, and the transition of C. albicans were assessed following cell and tis...
متن کامل